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You could Have a blog on the other domain with links to your main site, should be good for SEO and keeping visitors interested as well.
My target market is global rather than national
Use the .com as your main domain in this case and place a 301 redirect from your .co.uk to your .com.
If you have a concentration of target clients in a certain area e.g. North Amercia, host your site in the US, and vice versa for Europe etc.
Ronnie