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It all depends if you've built your email list from opt-in subscribers who are potentially interested in your product. If you've bought a list or harvested the email addresses at random, then it probably won't be very efficient.
Is that where on the website when you buy something you have the option to opt out of the there news letter?
Even if I opt out on most websites they still add you to there spam list.
Just my opinion though cant stand spam/advertising emails.